Transgenic An organism that is artificially modified through the implantation of heterologous DNA into one or more of its cells. Related Topics: Genetics Contributed by: BU Search

Robl ) on the production of transgenic cattle. Dr. Cibelli is one of the pioneers in the area of cloning with transgenic somatic cells in bovine for the production of animals and embryonic stem cell -like cells. His work was focused in the

successful in producing transgenic swine and mice, and more recently the laboratory reported the production of the first cloned transgenic goats using novel somatic cell nuclear transfer methods (Baguisi et al, 1999). Moreover, this work has

< ~ 98% of offspring are transgenic , demonstrates stable transgene integration & expression Germline transgenesis Less costly due to transfection/selection in vitro Disadvantages Methodology not optimized in

05/99 Cloned transgenic goats 05/99 Interspecies embryos produced Chronology of HARTs and Related Animal Studies --- High Impact Claims

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Transgenic ES-like cells were injected into preimplantation embryos and transferred into surrogate mothers Six out of seven animals born were found onimeric for at least one tissue and overall onimerism was

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